Lithium Hydroxide → HCID 67355400, compound

Participants

Reaction Conditions

Reaction Steps

Treat a solution of 4′-{3-[4-(tert-butyl-diphenyl-silanyloxy)-cyclohexyl]-2-oxo-pyrrolidin-1-ylmethyl}-3′,5′-dichloro-biphenyl-4-carboxylic acid methyl ester (0.56 g) in THF (5 mL ) and methanol (1 mL) with 2N LiOH (5 mL) and stir at 50° C. for 2 hours. Cool the reaction, dilute with ethyl acetate (25 mL), and wash with 1 N HCl (10 mL). Dry the organic layer (Na2SO4) and remove the solvent in vacuo to afford 0.55 g (99%) of the title compound. MS (m/z): 700 (M+).

Provenance & Evidence