1,1'-Carbonyldiimidazole → HCID 67354701, compound

Participants

Reaction Steps

Treat a solution of 4′-{3-[4-(tert-Butyl-diphenyl-silanyloxy)-cyclohexyl]-2-oxo-pyrrolidin-1-ylmethyl}-3′,5′-dichloro-biphenyl-4-carboxylic acid (0.35 g, 0.5 mmol) in CH2Cl2 (20 mL) with 1,1′-carbonyldiimidazole (0.162 g, 1.0 mmol) and stir for 45 minutes at room temperature. Treat the reaction with 4-trifluoromethylpiperidine hydrochloride (0.142 g, 0.75 mmol) and diisopropylethylamine (0.097 g, 0.75 mmol), and stir for 12 hours at room temperature. Load the mixture on silica gel column and flash with 25% to 50% ethyl acetate in hexanes to afford 0.21 g (50%) of the title compound. MS (m/z): 835 (M+).

Provenance & Evidence