Sodium Hydroxide → HCID 24852104, compound

Participants

Reaction Conditions

Reaction Steps

Treat a solution of 3′,5′-dichloro-4′-(3-cyclohexyl-2-oxo-pyrrolidin-1-ylmethyl)-biphenyl-4-carboxylic acid methyl ester (0.6 g) in THF (15 mL) with 5N NaOH (5 mL) and stir at 50° C. for 12 hours. Quench the reaction with HCl (1N, 25 mL). Partition the mixture between ethyl acetate and water. Dry the organic layer (Na2SO4) and remove the solvent in vacuo to afford 0.56 g (96%) of the title compound. MS (m/z): 446 (M+).

Provenance & Evidence