Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 4-Fluorophenol | HCID 9732 | — |
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 2(1H)-Pyrimidinone, tetrahydro-1,3-dimethyl- | HCID 81646 | — |
| Reactant | Chloroform methanol | HCID 21584188 | — |
| Product | HCID 57782360 | HCID 57782360 | — |
Reaction Steps
A mixture of the compound obtained in Example 5-(2) (13.20 g), 4-fluorophenol (12.86 g), Cs2CO3 (49.9 g) and DMPU (15 ml) was stirred at 200° C. for 2 hours. After cooling to room temperature, MeOH/CHCl3 (MeOH/CHCl3=20%) was added and insoluble materials were filtered off. The filtrate was concentrated, and the resulting crude product was purified by column chromatography (OH-type neutral SiO2, AcOEt/hexane=0% to 30%) to give the titled compound (22.37 g, light-yellow oil).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07994204B2 |
|---|
| Source dataset | uspto-grants-2011_08 |
|---|
| ORD ID | ord-e7a0e6f7b77b4b209ffaf9f121f5146d |
|---|
| Source note | uspto-grants-2011_08 |
|---|
