Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 4-Fluorophenol | HCID 9732 | — |
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 2(1H)-Pyrimidinone, tetrahydro-1,3-dimethyl- | HCID 81646 | — |
| Solvent | Ethyl acetate hexane | HCID 21226206 | — |
| Product | HCID 57782285 | HCID 57782285 | — |
Reaction Steps
A suspension of the compound obtained in Example 7-(1) (5.0 g), 4-fluorophenol (2.87 g) and Cs2CO3 (10.4 g) in DMPU (10 ml) was stirred at 200° C. for 1 hour. After cooling to room temperature, the reaction mixture was diluted with methanol/chloroform (1/4) and filtered. The filtrate was concentrated, and the resulting residue was purified by column chromatography (OH-type SiO2, AcOEt/hexane=0% to 30%) to give the titled compound (4.16 g) as a light-pink liquid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07994204B2 |
|---|
| Source dataset | uspto-grants-2011_08 |
|---|
| ORD ID | ord-82e7df02b0c449319b2557fb0eb3c72c |
|---|
| Source note | uspto-grants-2011_08 |
|---|
