Dimethylamine → HCID 58580003, compound

Participants

Reaction Steps

A solution of dimethylamine (2.0 M, 24 ml, 48 mmol) in THF was added to a solution of 2-bromo-bicyclo[3.2.0]heptan-3-ol (4.00 g, 19.5 mmol) in acetone (40 ml) at 0° C. and the mixture allowed to warm to ambient temperature over 1 h and stirred at ambient temperature overnight. The orange solution was filtered and the filtrate was evaporated to dryness. Purification was achieved by column chromatography on silica gel using 5% MeOH in DCM to yield 3.01 g (91%) of the product as a tan powder. LC-MS (Method 2): Rt 0.37 min, m/z 170.09 [MH]+.

Provenance & Evidence