Imidazole → Silane, [(9-bromononyl)oxy](1,1-dimethylethyl)dimethyl-

Participants

Reaction Steps

Tert-butyl-dimethylsilyl chloride (28.16 g, 186.8 mmol) was added in portions to a solution of 9-bromo-nonan-1-ol (27.8 g, 124.6 mmol) and imidazole (25.4 g, 373 mmol) in dry DCM (400 mL) at −10° C. under a nitrogen atmosphere. The reaction mixture was allowed to warm to RT overnight. The solids were removed by filtration and the filtrate was washed with 10% citric acid (aq), then brine, dried (MgSO4), filtered, and concentrated to dryness to afford the title compound as a yellow oil.

Provenance & Evidence