2-Methylpropanethioamide → HCID 57989663, compound

HRID 1670912Notes

Reaction equation

HRID 1670912 reaction equation
ClC1N=C(C2SC(N3CCCC3)=NC=2C2C=C(NS(C3C(F)=CC=CC=3F)(=O)=O)C=CC=2)C=CN=1.[Cl:36][C:37]1[N:42]=[C:41]([CH2:43][C:44]([C:46]2[CH:47]=[C:48]([NH:52][C:53](=[O:58])[O:54][CH2:55][CH:56]=[CH2:57])[CH:49]=[CH:50][CH:51]=2)=O)[CH:40]=[CH:39][N:38]=1.[CH3:59][CH:60]([CH3:64])[C:61](=[S:63])[NH2:62]>>[Cl:36][C:37]1[N:42]=[C:41]([C:43]2[S:63][C:61]([CH:60]([CH3:64])[CH3:59])=[N:62][C:44]=2[C:46]2[CH:47]=[C:48]([NH:52][C:53](=[O:58])[O:54][CH2:55][CH:56]=[CH2:57])[CH:49]=[CH:50][CH:51]=2)[CH:40]=[CH:39][N:38]=1

Participants

4

Reactant 3

HCID 109095072-Methylpropanethioamide2×HCID 57989807N-{3-[5-(2-Chloro-4-pyrimidinyl)-2-(1-pyrrolidinyl)-1,3-thiazol-4-yl]phenyl}-2,6-difluorobenzenesulfonamideHCID 579899812-Propen-1-yl {3-[(2-chloro-4-pyrimidinyl)acetyl]phenyl}carbamate

Product 1

HCID 57989663HCID 57989663, compoundYield 45.9%

Procedure

Following a procedure analogous to the procedure described in Intermediate 6, using 2-propen-1-yl {3-[(2-chloro-4-pyrimidinyl)acetyl]phenyl}carbamate (10.0 g, 30.14 mmol), and 2-methylpropanethioamide (3.73 g, 36.17 mmol), prepared by a procedure analogous to Intermediate 1, 5.74 g of the title compound was obtained. MS (ESI): 415 [M+H]+.

Sources & evidence

ORD record
ord-e88071e6a17f4fd9b769c1f5d75b38e1
Source dataset
uspto-grants-2011_08
Patent number
US07994185B2

Reaction notes

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