HCID 57989726, compound → HCID 57989989, compound

HRID 1670982Notes

Reaction equation

HRID 1670982 reaction equation
ClC1N=C(C2SC(C(C)C)=NC=2C2C=C(C=CC=2)N)C=CN=1.[Cl:23][C:24]1[C:29]([C:30]2[N:31]=[C:32]([N:42]3[CH2:47][CH2:46][O:45][CH2:44][CH2:43]3)[S:33][C:34]=2[C:35]2[CH:40]=[CH:39][N:38]=[C:37]([Cl:41])[N:36]=2)=[CH:28][CH:27]=[CH:26][C:25]=1[NH:48]C(=O)OCC=C>>[Cl:23][C:24]1[C:29]([C:30]2[N:31]=[C:32]([N:42]3[CH2:47][CH2:46][O:45][CH2:44][CH2:43]3)[S:33][C:34]=2[C:35]2[CH:40]=[CH:39][N:38]=[C:37]([Cl:41])[N:36]=2)=[CH:28][CH:27]=[CH:26][C:25]=1[NH2:48]

Participants

3

Reactant 2

HCID 57989726HCID 57989726, compoundHCID 579900463-[5-(2-Chloro-4-pyrimidinyl)-2-(1-methylethyl)-1,3-thiazol-4-yl]aniline

Product 1

HCID 57989989HCID 57989989, compound

Procedure

Following a procedure analogous to the procedure described in Intermediate 13 using 2-propen-1-yl {2-chloro-3-[5-(2-chloro-4-pyrimidinyl)-2-(4-morpholinyl)-1,3-thiazol-4-yl]phenyl}carbamate (2.50 g, 5.08 mmol) the title compound of Step D was obtained as a yellow solid (2.08 g, 4.99 mmol, 98% yield). MS (ESI): 407.97 [M+H]+.

Sources & evidence

ORD record
ord-9c91e40d058a42868957e4ee741f2206
Source dataset
uspto-grants-2011_08
Patent number
US07994185B2

Reaction notes

Loading…