3-Fluorobenzenesulfonyl Chloride → HCID 57989836, compound

HRID 1671158Notes

Reaction equation

HRID 1671158 reaction equation
ClC1N=C(C2SC(C(C)C)=NC=2C2C=C(NS(C3C(F)=CC=CC=3F)(=O)=O)C=CC=2)C=CN=1.[CH3:34][C:35]([C:38]1[S:39][C:40]([C:51]2[CH:56]=[CH:55][N:54]=[CH:53][N:52]=2)=[C:41]([C:43]2[C:44]([F:50])=[C:45]([CH:47]=[CH:48][CH:49]=2)[NH2:46])[N:42]=1)([CH3:37])[CH3:36].[F:57][C:58]1[CH:59]=[C:60]([S:64](Cl)(=[O:66])=[O:65])[CH:61]=[CH:62][CH:63]=1>>[CH3:37][C:35]([C:38]1[S:39][C:40]([C:51]2[CH:56]=[CH:55][N:54]=[CH:53][N:52]=2)=[C:41]([C:43]2[C:44]([F:50])=[C:45]([NH:46][S:64]([C:60]3[CH:61]=[CH:62][CH:63]=[C:58]([F:57])[CH:59]=3)(=[O:66])=[O:65])[CH:47]=[CH:48][CH:49]=2)[N:42]=1)([CH3:34])[CH3:36]

Participants

4

Reactant 3

HCID 27342583-Fluorobenzenesulfonyl ChlorideHCID 57989889HCID 57989889, compoundHCID 57990030N-{3-[5-(2-chloro-4-pyrimidinyl)-2-(1-methylethyl)-1,3-thiazol-4-yl]phenyl}-2,6-difluorobenzenesulfonamide

Product 1

HCID 57989836HCID 57989836, compound

Procedure

Following a procedure analogous to the procedure described in Intermediate 14 using 3-[2-(1,1-dimethylethyl)-5-(4-pyrimidinyl)-1,3-thiazol-4-yl]-2-fluoroaniline (70 mg, 0.213 mmol) and 3-fluorobenzenesulfonyl chloride (124 mg, 0.639 mmol), the title compound was obtained as a solid (76 mg, 73% yield). MS (ESI): 488 [M+H]+.

Sources & evidence

ORD record
ord-247e49871ebb4eddb91e17d8fa4b3a54
Source dataset
uspto-grants-2011_08
Patent number
US07994185B2

Reaction notes

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