Ammonium Hydroxide → HCID 67312392, compound

Participants

Reaction Steps

Following a procedure analogous to the procedure described in Example 282 using N-{3-[5-(2-chloro-4-pyrimidinyl)-2-(tetrahydro-2H-pyran-4-yl)-1,3-thiazol-4-yl]-2-fluorophenyl}-1-methyl-1H-pyrazole-3-sulfonamide (640 mg, 1.19 mmol) and ammonium hydroxide (15 ml), the title compound was obtained as a white solid (340 mg, 51.5%). 1HNMR (MEOD-d4): δ ppm 7.93-7.95 (d, J=6.0 Hz, 1H), 7.59-7.59 (d, J=2.0 Hz, 1H), 7.46-7.50 (dd, J1=7.8 Hz, J2=1.6 Hz, 1H), 7.24-7.28 (dd, J1=6.8 Hz, J2=1.6 Hz, 1H), 7.15-7.18 (t, J=7.8 Hz, 1H), 6.54-6.55 (d, J=2.4 Hz, 1H), 6.32-6.34 (d, J=6.0 Hz, 1H), 3.92-3.96 (dd, J1=11.6 Hz, J2=2.4 Hz, 1H), 3.80 (s, 3H), 3.45-3.51 (dd, J1=11.6 Hz, J2=2.0 Hz, 2H), 3.21-3.28 (m, 1H), 1.96-2.00 (dd, J1=12.8 Hz, J2=2.4 Hz, 2H), 1.75-1.85 (dd, J1=12.2 Hz, J2=4.4 Hz, 2H); MS: 516 [M+H]+.

Provenance & Evidence