1-(Benzofuran-5-yl)-2-bromopropan-1-one → 3-(Benzofuran-5-yl)-7-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-2,6-dimethylpyrazolo[5,1-b]oxazole

HRID 1671317Notes

Reaction equation

HRID 1671317 reaction equation
[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([C:10](=O)[CH:11](Br)[CH3:12])=[CH:9][C:4]=2[CH:3]=[CH:2]1.[CH3:15][C:16]1[N:20]=[C:19]([CH3:21])[N:18]([C:22]2[C:26]([CH3:27])=[N:25][NH:24][C:23]=2[OH:28])[N:17]=1>>[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([C:10]3[N:24]4[N:25]=[C:26]([CH3:27])[C:22]([N:18]5[C:19]([CH3:21])=[N:20][C:16]([CH3:15])=[N:17]5)=[C:23]4[O:28][C:11]=3[CH3:12])=[CH:9][C:4]=2[CH:3]=[CH:2]1

Participants

3

Reactant 2

HCID 866389381-(Benzofuran-5-yl)-2-bromopropan-1-oneHCID 178432945HCID 178432945, compound

Product 1

HCID 672123953-(Benzofuran-5-yl)-7-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-2,6-dimethylpyrazolo[5,1-b]oxazole

Procedure

The title compound is prepared from 1-(benzofuran-5-yl)-2-bromopropan-1-one (step 3) and 4-(3,5-dimethyl-[1,2,4]triazol-1-yl)-5-methyl-2H-pyrazol-3-ol (Intermediate KF) analogously to Example 6.2. MS: m/z 348.1 [M+H]+.

Sources & evidence

ORD record
ord-b573c299bd28450aab5b96b801c77517
Source dataset
uspto-grants-2011_08
Patent number
US07994203B2

Reaction notes

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