Lithium hydroxide, monohydrate → HCID 59186045, compound

Participants

Reaction Steps

A suspension containing 3-(2,4-dichloro-phenyl)-6-ethyl-2-methyl-pyrazolo[5,1-b]oxazole-7-carboxylic acid ethyl ester (1.80 g, 4.90 mmol) and lithium hydroxide monohydrate (1.0 g, 24.51 mmol) is heated at 70° C. in a 3/1 mixture of methanol/water (32 ml) for 2 hrs. The resulting solution is cooled to RT, diluted with water (60 ml) and glacial acetic acid added (approx. 3 ml) to adjust the pH to 4-5. The resultant suspension is stirred for 1 h and filtered and washed with water. The product is dried in vacuo at 50° C.; MS: m/z 339.03 [M+H]+

Provenance & Evidence