Thionyl Chloride → HCID 59186036, compound

Participants

Reaction Steps

A mixture comprising 3-(2,4-dichloro-phenyl)-2,6-dimethyl-pyrazolo[5,1-b]oxazole-7-carboxylic acid (Intermediate IBB) (1 g, 3.08 mmol) and SOCl2 (10 ml, 137 mmol) is heated at reflux for 2 hours. After cooling to room temperature excess SOCl2 is removed under vacuum. The resulting solid is azeotroped with toluene until any remaining SOCl2 is removed to afford the title compound as a solid; 1H NMR (400 MHz, CDCl3) δ 2.48 (s, 3H), 2.53 (s, 3H), 7.48 (q, 1H), 7.52 (q, 1H), 7.62 (d, 1H).

Provenance & Evidence