N-bromobutanimide → HCID 67212702, compound

Participants

Reaction Steps

To a solution of 3-(2,4-dichloro-phenyl)-2,6-dimethyl-pyrazolo[5,1-b]oxazole (Intermediate HE) (0.755 g, 2.69 mmol) in DMF (10 ml) is added NBS (0.502 g, 2.82 mmol). The reaction is stirred at RT for 30 mins and then partitioned between Na2CO3 and EtOAc. The mixture is extracted with EtOAc (×2) and the combined organic phases are dried over Na2SO4, filtered and evaporated to dryness under reduced pressure. This resulting solid is recrystallised from hot EtOAc/iso-hexane to yield the title compound. MS: m/z 360.99 [M+H]+

Provenance & Evidence