Potassium Carbonate → HCID 67212568, compound

Participants

Reaction Conditions

Reaction Steps

To a stirring solution of 5-methyl-3-(trifluoromethyl)-1H-1,2,4-triazole (2 g, 13.24 mmol) in THF (60 ml) is added K2CO3 (3.66 g, 26.5 mmol). The mixture is allowed to stir for 20 minutes at 40° C. before adding ethyl 2-chloro-3-oxobutanoate (2.61 g, 15.88 mmol) and leaving to stir. The reaction mixture is filtered to remove solids, before concentrating under vacuum to yield a dark orange/red oil. The oil is taken up in 2% MeOH in DCM and purified on silica eluting with 2% MeOH in DCM to afford the title compound as a pale yellow oil. MS m/z 280.0 [M+H]+

Provenance & Evidence