Hydrazine → HCID 178434686, compound

HRID 1671351Notes

Reaction equation

HRID 1671351 reaction equation
C(O[C:4](=[O:19])[CH:5]([N:9]1[C:13]([CH3:14])=[N:12][C:11]([C:15]([F:18])([F:17])[F:16])=[N:10]1)[C:6](=O)[CH3:7])C.[NH2:20][NH2:21]>CCO>[CH3:7][C:6]1[C:5]([N:9]2[C:13]([CH3:14])=[N:12][C:11]([C:15]([F:16])([F:17])[F:18])=[N:10]2)=[C:4]([OH:19])[NH:20][N:21]=1

Participants

4

Reactant 2

HCID 9321HydrazineHCID 67212568HCID 67212568, compound

Product 1

HCID 178434686HCID 178434686, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
50 °C

Procedure

To a solution of 2-(5-methyl-3-trifluoromethyl-[1,2,4]triazol-1-yl)-3-oxo-butyric acid ethyl ester (890 mg, 3.19 mmol) in EtOH (15 ml) is added hydrazine (0.500 ml, 15.94 mmol) and the mixture left to stir at 50° C. overnight. The solvent is removed in vacuo and trituration of the resulting pale yellow oil with ether and EtOAc affords the title compound as a fine white solid.

Workup

  1. waitthe mixture left
  2. customThe solvent is removed in vacuo and trituration of the resulting pale yellow oil with ether and EtOAc

Sources & evidence

ORD record
ord-7f233881c19144fd8bceedd59b0f0867
Source dataset
uspto-grants-2011_08
Patent number
US07994203B2

Reaction notes

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