HuagongsheHuagongshe Chemistry Print Report · For research reference only
Orotic Acid → 2,6-Dioxo-1,2,3,6-tetrahydropyrimidine-4-carbonyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Orotic Acid | HCID 967 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | Methyl 1,2,3,6-tetrahydro-2,6-dioxo-4-pyrimidinecarboxylate | HCID 80257 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | 2,6-Dioxo-1,2,3,6-tetrahydropyrimidine-4-carbonyl chloride | HCID 20491043 | — |
Reaction Steps
Org. Chem, 27, 3507 (1962) describes that methyl orotate can be synthesized by reacting orotic acid with thionyl chloride in the presence of a catalytic amount of pyridine to give orotyl chloride, which is then heated in methanol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07994315B2 |
| Source dataset | uspto-grants-2011_08 |
| ORD ID | ord-9bd61611db3047709e6cdaf9866f4a03 |
| Source note | uspto-grants-2011_08 |