Ethyl chloroformate → Ethyl (2s)-2-(4-fluorophenyl)morpholine-4-carboxylate

Participants

Reaction Steps

To a solution of (2S)-2-(4-fluorophenyl)-4-(benzyl)morpholine (1.00 g, 3.67 mmol) in toluene (10 mL) was added a solution of ethyl chloroformate (0.39 mL, 4.04 mmol) in toluene (5 mL) at 89° C. The mixture was stirred for 3 hrs and the solvent was evaporated to give ethyl (S)-2-(4-fluorophenyl)morpholine-4-carboxylate (1.17 g) as a black oil.

Provenance & Evidence