HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzenesulfonic Acid → Clopidogrel Besylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzenesulfonic Acid | HCID 7371 | — |
| Reactant | Clopidogrel | HCID 60606 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | Clopidogrel Besylate | HCID 9847991 | — |
Reaction Steps
Clopidogrel base was dissolved in THF. To it, benzene sulfonic acid was added at 20° C., and the reaction mixture was heated to reflux temperature for 2 to 10 hr. The solvent was evaporated to dryness under reduced pressure to obtain Clopidogrel besylate, which on characterization showed to be the amorphous form.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07994322B2 |
| Source dataset | uspto-grants-2011_08 |
| ORD ID | ord-8f61e35377a642ed8358008add610e94 |
| Source note | uspto-grants-2011_08 |