Benzenesulfonic Acid → Clopidogrel Besylate

Participants

Reaction Steps

Clopidogrel base (10 g) was dissolved in decan-1-ol at 50-55° C. To this, benzene sulfonic acid (5 g) was added at 50-55° C. and the reaction mixture was stirred for about 20 hr. The solid was filtered and washed with methyl tertiary butyl ether and dried in vacuum oven for at least 20 hr., to give Clopidogrel besylate, which on characterization was found to be crystalline form. M.P. 130-135° C.

Provenance & Evidence