Benzenesulfonic Acid → Clopidogrel Besylate

Participants

Reaction Steps

Clopidogrel base (30 g) was dissolved in isopropanol at 50-55° C. To this mixture benzene sulphonic acid (15 g) was added at 50-55° C. The reaction mixture was stirred for 20 hr. The solid was filtered and washed with cold isopropanol and dried in a vacuum oven for at least 20 hr. to give Clopidogrel besylate, which on characterization was found to be crystalline form. M.P. 130-135° C.

Provenance & Evidence