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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1671552Generated: October 27, 2026

(R)-Indan-1-yl-(5-nitro-quinolin-2-yl)-amine → (R)-N2-Indan-1-yl-quinoline-2,5-diamine

https://huagongshe.com/reaction/1671552

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(R)-Indan-1-yl-(5-nitro-quinolin-2-yl)-amineHCID 67096022—
ReactantHCID 178418361HCID 178418361—
CatalystPalladiumHCID 23938—
SolventEthanolHCID 702—
Product(R)-N2-Indan-1-yl-quinoline-2,5-diamineHCID 44219082—

Reaction Steps

(R)-Indan-1-yl-(5-nitro-quinolin-2-yl)-amine (2.66 g, 8.7 mmol) was dissolved in 420 mL ethanol. Palladium on charcoal (10%, 463 mg, 0.4 mmol) was added and the reaction mixture war hydrogenated with a hydrogen balloon overnight. The palladium was filtered off and the solvent was evaporated. The title compound was obtained as a brown solid (2.29 g, 95%), MS: m/e=276.3 (M+H+).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07994324B2
Source datasetuspto-grants-2011_08
ORD IDord-9640605f56da41fca579637f2b8d52f3
Source noteuspto-grants-2011_08