Dimethylsulphamoyl chloride → Rac-n'-{2-[(7-methoxy-indan-1-yl)amino]quinolin-5-yl}-n,n-dimethylsulfamide

HRID 1671556Notes

Reaction equation

[CH3:1][O:2][C:3]1[CH:4]=[CH:5][CH:6]=[C:7]2[C:11]=1[CH:10]([NH:12][C:13]1[CH:22]=[CH:21][C:20]3[C:19]([NH2:23])=[CH:18][CH:17]=[CH:16][C:15]=3[N:14]=1)[CH2:9][CH2:8]2.[CH3:24][N:25]([CH3:30])[S:26](Cl)(=[O:28])=[O:27]>>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][CH:6]=[C:7]2[C:11]=1[CH:10]([NH:12][C:13]1[CH:22]=[CH:21][C:20]3[C:15](=[CH:16][CH:17]=[CH:18][C:19]=3[NH:23][S:26]([N:25]([CH3:30])[CH3:24])(=[O:28])=[O:27])[N:14]=1)[CH2:9][CH2:8]2

Participants

Reactant 2

HCID 83372Dimethylsulphamoyl chloride

HCID 44219236n2-(7-Methoxy-indan-1-yl)-quinoline-2,5-diamine

Product 1

HCID 44199396Rac-n'-{2-[(7-methoxy-indan-1-yl)amino]quinolin-5-yl}-n,n-dimethylsulfamide

Procedure

The title compound, MS: m/e=413.4 (M+H+), was prepared in accordance with the general method of example 17 from N2-(7-methoxy-indan-1-yl)-quinoline-2,5-diamine and dimethyl sulfamoyl chloride.

Sources & evidence

ORD record: ord-7c28005fd30e4931a9619f6960b47838
Source dataset: uspto-grants-2011_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07994324B2

Reaction notes

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