1,10-Phenanthroline → HCID 44219391, compound

Participants

Reaction Conditions

Reaction Steps

(R)-Indan-1-yl-(5-iodo-quinolin-2-yl)-amine (250 mg, 0.6 mmol) were dissolved in toluene (2 mL). 2-Hydroxyethyl-methylsulfide (0.17 □L, 1.8 mmol), copper iodide (12 mg), cesium carbonate (420 mg, 1.2 mmol) and phenantroline (23 mg) were added. The reaction mixture was stirred for 48 h at 110° C. The reaction mixture was extracted with water (2×10 mL). The organic phase was dried on sodium sulfate and evaporated. The residue was subjected to column chromatography (silica gel, heptane:ethyl acetate 10:0→3:2) to yield the title compound as brown oil (80 mg, 35%); MS: m/e=351.6 (M+H+).

Provenance & Evidence