Hydroxyamine hydrochloride → 4-Methoxy-benzofuran-3-one oxime

Participants

Reaction Steps

A mixture of 4-methoxy-benzofuran-3-one (CAS 7169-35-9) (4.9 g, 19 mmol), sodium acetate (3.06 g, 38 mmol) and hydroxylamine hydrochloride (2.58 g, 38 mmol) in EtOH (40 ml) was refluxed for 6 h. Cooled to room temperature, filtered the precipitate off, washed with EtOH and dried in high vacuum to give 4-methoxy-benzofuran-3-one oxime as a white solid (5.93 g, 100%); MS: m/e=180.2 (M+H+).

Provenance & Evidence