HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Aminotetrahydropyran → Rac-n2-(4-methoxy-2,3-dihydro-benzofuran-3-yl)-n5-(tetrahydro-pyran-4-yl)-quinoline-2,5-diamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Aminotetrahydropyran | HCID 419223 | — |
| Reactant | 2-Chloro-5-iodoquinoline | HCID 45789424 | — |
| Reactant | 4-Methoxy-benzofuran-3-one oxime | HCID 86634184 | — |
| Product | Rac-n2-(4-methoxy-2,3-dihydro-benzofuran-3-yl)-n5-(tetrahydro-pyran-4-yl)-quinoline-2,5-diamine | HCID 44217194 | — |
Reaction Steps
The title compound, light yellow foam, MS: m/e=392.3 (M+H+), was prepared in accordance with the general method of example 1 from 5-iodo-2-chloroquinoline, (RS)-4-methoxy-2,3-dihydro-benzofuran-3-ylamine (example 39, step A and B) and commercially available 4-amino-tetrahydropyran.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07994324B2 |
| Source dataset | uspto-grants-2011_08 |
| ORD ID | ord-0fea1a0db2784758bebeff53bcac8001 |
| Source note | uspto-grants-2011_08 |