(4-Methylpiperazin-1-yl)acetic acid → N-[2-((S)-Indan-1-ylamino)-quinolin-5-yl]-2-(4-methyl-piperazin-1-yl)-acetamide

HRID 1671571Notes

Reaction equation

HRID 1671571 reaction equation
[C@H:1]1([NH:10][C:11]2[CH:20]=[CH:19][C:18]3[C:17]([NH2:21])=[CH:16][CH:15]=[CH:14][C:13]=3[N:12]=2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][CH2:2]1.[CH3:22][N:23]1[CH2:28][CH2:27][N:26]([CH2:29][C:30](O)=[O:31])[CH2:25][CH2:24]1>>[C@@H:1]1([NH:10][C:11]2[CH:20]=[CH:19][C:18]3[C:13](=[CH:14][CH:15]=[CH:16][C:17]=3[NH:21][C:30](=[O:31])[CH2:29][N:26]3[CH2:27][CH2:28][N:23]([CH3:22])[CH2:24][CH2:25]3)[N:12]=2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 2762732(4-Methylpiperazin-1-yl)acetic acidHCID 44219082(R)-N2-Indan-1-yl-quinoline-2,5-diamine

Product 1

HCID 44217196N-[2-((S)-Indan-1-ylamino)-quinolin-5-yl]-2-(4-methyl-piperazin-1-yl)-acetamide

Procedure

The title compound, light yellow oil, MS: m/e=416.4 (M+H+), was prepared in accordance with the general method of example 32 from (R)—N2-indan-1-yl-quinoline-2,5-diamine (example 16) and commercially available (4-methyl-piperazin-1-yl)-acetic acid.

Sources & evidence

ORD record
ord-59979909489f4cdb8a164d14f0b28c46
Source dataset
uspto-grants-2011_08
Patent number
US07994324B2

Reaction notes

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