1,2-Dichloroethane → HCID 11848594, compound

Participants

Reaction Steps

Triethylamine (410 μL, 2.94 mmol) was added to a solution of [5-bromo-2-oxo-1-(2,2,2-trifluoroethyl)-1,2-dihydropyridin-3-yl]acetic acid (231 mg, 0.736 mmol), 2-oxo-1-(4-piperidinyl)-2,3-dihydro-1H-imidazo[4,5-b]pyridine dihydrochloride (236 mg, 0.809 mmol), EDC (212 mg, 1.10 mmol), and HOAt (100 mg, 0.736 mmol) in DMF (13 mL). After 24 h, saturated aqueous sodium bicarbonate was added and the mixture was extracted with ethyl acetate (3×). The organic layers were dried over sodium sulfate, filtered and concentrated. Purification by silica gel chromatography [100% dichloromethane→90% dichloromethane/methanol] gave the title compound (0.192 g). MS 516.0 (M+1).

Provenance & Evidence