Methyl morpholine oxide → HCID 59858030, compound

Participants

Reaction Steps

Tetrapropylammonium perruthenate (0.07 mmol, 5 mol %) was added to a stirred solution of [6-(4-tert-butoxycarbonylamino-2-hydroxy-cyclopentylmethyl)-pyridin-2-yl]-carbamic acid tert-butyl ester IV-3 (0.14 mmol) and N-methylmorpholine-N-oxide (0.26 mmol) in dichloromethane (9 mL) and acetonitrile (1 mL) at room temperature, and was allowed to react overnight. When complete, the solvent was evaporated in vacuo and the residue was purified by column chromatography (silica gel, CH2Cl2:EtOAc, 8:2) to afford pure product as a white solid (67%).

Provenance & Evidence