HCID 25209347, compound → HCID 25209042, compound

Participants

Reaction Steps

A suspension of V-2 (0.003 mol), such as 2-[benzyl(3-fluorophenethyl)amino]ethanol (0.82 g), and 10% Palladium on activated carbon (Pd/C, 450 mg) in MeOH (30 mL) was stirred at room temperature under hydrogen atmosphere overnight. The catalyst was then filtered out through celite. The celite pad was washed with MeOH (10 mL×3). The filtrate was concentrated in vacuo. The residue was purified by column chromatography (silica gel, CH2Cl2:MeOH=8.5:1.5) to yield pale-yellow oil (V-3, 0.45 g, 82%).

Provenance & Evidence