Trifluoroacetic acid → HCID 178477651, compound

Participants

Reaction Steps

Sodium nitrite (5 mg) was added to a trifluoroacetic acid (1 ml) solution of 5-(6-(4-(ethylsulfonyl)phenoxy)-2-pyrazin-2-yl-1H-benzimidazol-5-yl)tetrahydrofuran-2-ol (3.3 mg) obtained in Example 9, and the reaction liquid was stirred at room temperature for 10 minutes. The solvent was evaporated away under reduced pressure, and the resulting residue was purified through reversed-phase middle-pressure liquid chromatography (ODS-AS-360-CC (by YMC), mobile phase: water/acetonitrile/0.1% trifluoroacetic acid), and the resulting fraction was diluted with ethyl acetate, washed with aqueous saturated sodium bicarbonate and saturated saline water in that order, and dried with anhydrous sodium sulfate. The solvent was evaporated away under reduced pressure to obtain the entitled compound as a yellow foamy substance.

Provenance & Evidence