Sulfuric Acid → HCID 178477642, compound

Participants

Reaction Steps

80% sulfuric acid (0.2 ml) was added to (6-(4-(ethylsulfonyl)phenoxy)-2-pyridin-2-yl-1H-benzimidazol-5-yl)((trimethylsilyl(oxy)acetonitrile (25 mg) obtained in Example 31 (step 1), and the reaction liquid was stirred at room temperature for 3 hours. The reaction mixture was purified through reversed-phase middle-pressure liquid chromatography (ODS-AS-360-CC (by YMC), mobile phase: water/acetonitrile/0.1% trifluoroacetic acid), and the resulting fraction was diluted with ethyl acetate, washed with aqueous saturated sodium bicarbonate and saturated saline water in that order, and dried with anhydrous sodium sulfate. The solvent was evaporated away under reduced pressure to obtain the entitled compound.

Provenance & Evidence