Sodium borohydride → HCID 178477644, compound

Participants

Reaction Conditions

Reaction Steps

Sodium borohydride (15 mg) was added to a methanol (1 ml) solution of methyl (6-(4-(ethylsulfonyl)phenoxy)-2-pyridin-2-yl-1H-benzimidazol-5-yl)(hydroxy)acetate (21 mg) obtained in Example 31 (step 2), and the reaction liquid was stirred overnight at 60° C. The solvent was evaporated away under reduced pressure, and the reaction mixture was purified through reversed-phase middle-pressure liquid chromatography (ODS-AS-360-CC (by YMC), mobile phase: water/acetonitrile/0.1% trifluoroacetic acid), and the resulting fraction was diluted with ethyl acetate, washed with aqueous saturated sodium bicarbonate and saturated saline water in that order, and dried with anhydrous sodium sulfate. The solvent was evaporated away under reduced pressure to obtain the entitled compound.

Provenance & Evidence