Methanol → Methyl 2-fluoro-4-nitrobenzoate

HRID 1671660Notes

Reaction equation

HRID 1671660 reaction equation
S(=O)(=O)(O)O.[F:6][C:7]1[CH:15]=[C:14]([N+:16]([O-:18])=[O:17])[CH:13]=[CH:12][C:8]=1[C:9]([OH:11])=[O:10].[CH3:19]O>>[F:6][C:7]1[CH:15]=[C:14]([N+:16]([O-:18])=[O:17])[CH:13]=[CH:12][C:8]=1[C:9]([O:11][CH3:19])=[O:10]

Participants

4

Reactant 3

HCID 887MethanolHCID 1118Sulfuric AcidHCID 3026792-Fluoro-4-nitrobenzoic acid

Product 1

HCID 3013872Methyl 2-fluoro-4-nitrobenzoate

Procedure

Concentrated sulfuric acid (5 ml) was added to a methanol (1300 ml) solution of 2-fluoro-4-nitrobenzoic acid (140 g), and heated under reflux for 48 hours. The solvent was evaporated away under reduced pressure, water was added to it, and the formed solid was taken out through filtration. After dried under reduced pressure, the entitled compound was obtained as a yellow solid.

Workup

  1. temperatureheated
  2. temperatureunder reflux for 48 hours
  3. customThe solvent was evaporated away under reduced pressure, water
  4. additionwas added to it
  5. filtrationthe formed solid was taken out through filtration
  6. customAfter dried under reduced pressure
  7. customthe entitled compound was obtained as a yellow solid

Sources & evidence

ORD record
ord-54c5adcb1a4140c1b230412f77f4fc8b
Source dataset
uspto-grants-2011_08
Patent number
US07994331B2

Reaction notes

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