Methyl 2-fluoro-4-nitrobenzoate → Methyl 4-amino-2-fluorobenzoate

Participants

Reaction Steps

Methyl 2-fluoro-4-nitrobenzoate (141 mg) was dissolved in methanol (1000 ml) and tetrahydrofuran (400 ml), and Raney nickel (20 g) was added to it, and stirred overnight in a hydrogen atmosphere. The catalyst was removed through filtration, and the solvent was evaporated away under reduced pressure to obtain methyl 4-amino-2-fluorobenzoate.

Provenance & Evidence