Nitric Acid → HCID 57433540, compound

HRID 1671663Notes

Reaction equation

HRID 1671663 reaction equation
[N+:1]([O-:4])(O)=[O:2].[F:5][C:6]1[CH:15]=[C:14]([NH:16][C:17]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][N:20]=2)=[O:18])[CH:13]=[CH:12][C:7]=1[C:8]([O:10][CH3:11])=[O:9]>C(=O)([O-])[O-].[Na+].[Na+]>[F:5][C:6]1[CH:15]=[C:14]([NH:16][C:17]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][N:20]=2)=[O:18])[C:13]([N+:1]([O-:4])=[O:2])=[CH:12][C:7]=1[C:8]([O:10][CH3:11])=[O:9]

Participants

4

Reactant 2

HCID 944Nitric AcidHCID 57433539Methyl 2-fluoro-4-[(pyridine-2-carbonyl)amino]benzoate

Product 1

HCID 57433540HCID 57433540, compound

Reagents, catalysts & solvents 1

HCID 10340Sodium CarbonateSolvent

Procedure

With cooling with ice, fuming nitric acid (110 ml) was gradually added to methyl 2-fluoro-4-[(2-pyridinylcarbonyl)amino]benzoate (27.7 g), and stirred at room temperature for 1.5 hours. With cooling with ice, the reaction liquid was gradually added to an aqueous solution (2000 ml) of sodium carbonate (138 g), and the formed solid was taken out through filtration. After dried under reduced pressure, the entitled compound was obtained as a yellow solid.

Workup

  1. temperatureWith cooling with ice
  2. customthe reaction liquid
  3. filtrationthe formed solid was taken out through filtration
  4. customAfter dried under reduced pressure
  5. customthe entitled compound was obtained as a yellow solid

Sources & evidence

ORD record
ord-f19ca06b113e4f64808c7f7153e5b9a6
Source dataset
uspto-grants-2011_08
Patent number
US07994331B2

Reaction notes

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