反应详情

With cooling with ice, fuming nitric acid (110 ml) was gradually added to methyl 2-fluoro-4-[(2-pyridinylcarbonyl)amino]benzoate (27.7 g), and stirred at room temperature for 1.5 hours. With cooling with ice, the reaction liquid was gradually added to an aqueous solution (2000 ml) of sodium carbonate (138 g), and the formed solid was taken out through filtration. After dried under reduced pressure, the entitled compound was obtained as a yellow solid.

1. temperatureWith cooling with ice
2. customthe reaction liquid
3. filtrationthe formed solid was taken out through filtration
4. customAfter dried under reduced pressure
5. customthe entitled compound was obtained as a yellow solid