HCID 57672582, compound → HCID 57672584, compound

HRID 1671670Notes

Reaction equation

HRID 1671670 reaction equation
[CH:1]1([N:4]2[C:8]([C:9]3[CH:14]=[CH:13][C:12]([N+:15]([O-])=O)=[C:11]([CH3:18])[CH:10]=3)=[N:7][N:6]=[N:5]2)[CH2:3][CH2:2]1.[H][H]>C(O)C.[C].[Pd]>[CH:1]1([N:4]2[C:8]([C:9]3[CH:14]=[CH:13][C:12]([NH2:15])=[C:11]([CH3:18])[CH:10]=3)=[N:7][N:6]=[N:5]2)[CH2:3][CH2:2]1

Participants

5

Reactant 2

HCID 57672582HCID 57672582, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 57672584HCID 57672584, compoundYield 72%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 702EthanolSolvent

Procedure

0.4 g of 5% palladium carbon was added to a solution of 1.6 g (6.5 mmol) of 4-(1-cyclopropyltetrazol-5-yl)-2-methylnitrobenzene in 70 ml of ethanol and the mixture was stirred under 3 atm hydrogen atmosphere overnight. The reaction mixture was filtered and concentrated under reduced pressure and the residual substance was purified with silica gel column chromatography to obtain 1.0 g of the desired compound.

Workup

  1. filtrationThe reaction mixture was filtered
  2. concentrationconcentrated under reduced pressure
  3. customthe residual substance was purified with silica gel column chromatography

Sources & evidence

ORD record
ord-5575b0cdede445ada7879c1ce00b8c84
Source dataset
uspto-grants-2011_08
Patent number
US07994339B2

Reaction notes

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