o-Phenylbenzoic acid → HCID 67018291, compound

Participants

Reaction Steps

To a mixture of 2-biphenylcarboxylic acid (107 mg), PyBOP (280 mg), DIEA (0.215 mL) in dry DMF (0.5 mL), was added a solution of 2-(N-Boc-aminomethyl)azetidine (100 mg) in dry DMF (0.5 mL). The resulting reaction mixture was stirred at RT for 20 h. The reaction mixture was diluted with EA, washed with water. The aqueous phase was extracted once again with EA, the combined organic extracts were dried (MgSO4), filtered and concentrated to yield the crude product as light brown oil. FC (EA) gave 140 mg (71%) of the title compound as a light yellow oil.

Provenance & Evidence