HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → HCID 67018182, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 2-Phenylbenzene-1-sulfonyl chloride | HCID 2756680 | — |
| Reactant | tert-Butyl [(azetidin-2-yl)methyl]carbamate | HCID 14280902 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 67018182 | HCID 67018182 | 68.3% |
Reaction Steps
To a cold (5° C.) solution of 2-(N-Boc-aminomethyl) azetidine (200 mg), DIEA (0.375 mL) in dry DMF (2 mL), was added portionwise biphenyl-2-sulfonyl chloride (272 mg). The reaction mixture was stirred at RT for 20 h. The reaction mixture was diluted with EA, washed with water. The organic extract was dried (MgSO4), filtered and concentrated to yield the crude product as light brown oil (295 mg, 68%) which was used for the next step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07994336B2 |
| Source dataset | uspto-grants-2011_08 |
| ORD ID | ord-61180db9338646299f9e7d1575a566b2 |
| Source note | uspto-grants-2011_08 |