Diisopropylethylamine → HCID 67018140, compound

Participants

Reaction Steps

To a cold (5° C.) solution of (2S)-benzofuran-4-carboxylic acid-(azetidine-2-ylmethyl)-amide hydrochloride (10 mg), DIEA (0.015 mL) in dry DMF (0.1 mL), was added portionwise 2-methoxy-benzoyl chloride (7.35 mg). The reaction mixture was stirred at RT for 20 h. The reaction mixture was diluted with EA, washed with water. The organic extract was dried (MgSO4), filtered and concentrated to yield a crude oil. FC (EA/n-heptane: 1/1) gave 7.3 mg (46%) of the title compound as a solid. LC-MS: rt=0.76 min, 365 [M+H]+.

Provenance & Evidence