4-(Trifluoromethyl)benzaldehyde → 3-Chloro-2-oxo-3-(4-trifluoromethyl-phenyl)-propionic acid methylester

HRID 1671684Notes

Reaction equation

HRID 1671684 reaction equation
[CH3:1][O:2][C:3](=[O:15])[C:4](=[O:14])[CH:5]([Cl:13])[C:6]1[CH:11]=[CH:10][C:9](F)=[CH:8][CH:7]=1.[F:16][C:17]([F:27])([F:26])C1C=CC(C=O)=CC=1.FC1C=CC(C=O)=CC=1>>[CH3:1][O:2][C:3](=[O:15])[C:4](=[O:14])[CH:5]([Cl:13])[C:6]1[CH:11]=[CH:10][C:9]([C:17]([F:27])([F:26])[F:16])=[CH:8][CH:7]=1

Participants

4

Reactant 3

HCID 679964-(Trifluoromethyl)benzaldehydeHCID 680234-FluorobenzaldehydeHCID 57437156Methyl 3-chloro-3-(4-fluorophenyl)-2-oxopropanoate

Product 1

HCID 200647133-Chloro-2-oxo-3-(4-trifluoromethyl-phenyl)-propionic acid methylester

Procedure

This compound was synthesised as 3-chloro-3-(4-fluoro-phenyl)-2-oxo-propionic acid methylester but using 4-trifluoromethylbenzaldehyde instead 4-fluorobenzaldehyde. 1H-NMR (CDCl3): δ=3.93 (s, 3H); 4.55 (s, 1H); 7.52 (d, 2H); 7.66 (d, 2H).

Sources & evidence

ORD record
ord-605714b8c5bc4f1ba64fd6ad1aa59ab6
Source dataset
uspto-grants-2011_08
Patent number
US07994336B2

Reaction notes

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