Water → 6-(Trifluoromethyl)imidazo[2,1-b][1,3]thiazole-5-carboxylic acid

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Reaction Steps

A solution of sodium chlorite 418.986 mg (4.633 mmol) and sodium dihydrogen phosphate dihydrate 553.971 mg (3.551 mmol) in water 3.94 mL (218.895 mmol) was added dropwise to a solution of 6-trifluoromethyl-imidazo[2,1-b]thiazole-5-carbaldehyde 119 mg (0.54 mmol) in t-BuOH (3.94 mL). The mixture was stirred for 2 h30 at RT. The mixture was then concentrated in vacuo to remove t-BuOH, a white precipitate was formed and filtered to give the title compound as a white solid (70 mg, 55%).

Provenance & Evidence