Sodium Hydroxide → HCID 178484813, compound

Participants

Reaction Conditions

Reaction Steps

The methyl cis-4-(methylamino)cyclohexanecarboxylate (3 g, 0.0175 mol) from above was dissolved in a THF/H2O (10 mL) mixture and was cooled to 0° C. Next 2 L of a 0.025 M solution of NaOH was added slowly. The mixture was stirred a 0° C. for another 0.5 hour. The mixture was then acidified to pH 7-8 and extracted with ethyl acetate. The water layer was acidified to pH 3-4 and extracted with ethyl acetate. The organic layer was dried over Na2SO4 and concentrated to give 2.49 g (0.016 mol, 90% yield) of product.

Provenance & Evidence