Cyanuric chloride → HCID 178525764, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of cyanuric chloride (493.65 mg, 2.7 mmol, 1 equivalent) in CH3CN/H2O (1/1, 20 ml) was cooled to 0° C. cis-4-aminocyclohexylcarboxylic acid (283.26 mg, 2.7 mmol, 1 equivalent) was added, followed by 1N NaOH (10.7 ml, 2 equivalents). The reaction was stirred at 0° C. for 15 min. LCMS analysis showed the complete consumption of the 2,4,6-trichloro-1,3,5-triazine. The crude product was used in the next step.

Provenance & Evidence