2-(Trifluoromethyl)benzylamine → HCID 178482417, compound

Participants

Reaction Steps

A solution of cis-4-(4-(methylamino)-6-(piperidin-1-yl)-1,3,5-triazin-2-ylamino)cyclohexanecarboxylic acid (7.6 mg, 0.023 mmol, 1 equivalent), 2-trifluoromethyl benzylamine (4 μL, 0.03 mmol, 1.25 equivalents) and DMAP (0.6 mg, 0.2 equivalents) in dichloromethane (1.5 ml) was cooled with stirring in an ice bath. EDCl (6.6 mg, 0.034 mmol, 1.5 equivalents) was added. The reaction mixture was stirred at 0° C. for 30 min and at room temperature for 2-3 hours. The solution was diluted with dichloromethane (1 ml), which was further washed with saturated sodium bicarbonate and water. The organic layer was dried and purified by HPLC (Luna 5μ C8(2), 100×21 mm, 28-70% CH3CN/H2O, 0.1% TFA, 20 min) to afford the final product (8.0 mg, yield 71%). MS (ES+): m/e 492.30 [M+H]+.

Provenance & Evidence