Acetonitrile--water (1/1) → HCID 178508803, compound

HRID 1671767Notes

Reaction equation

HRID 1671767 reaction equation
[NH2:1][C:2]1[N:7]=[C:6](Cl)[N:5]=[C:4]([NH:9][C@@H:10]2[CH2:15][CH2:14][C@H:13]([C:16]([OH:18])=[O:17])[CH2:12][CH2:11]2)[N:3]=1.[CH3:19][C:20]#[N:21].O>>[NH2:1][C:2]1[N:7]=[C:6]([N:21]2[CH2:12][CH2:11][CH2:10][CH2:15][CH2:19][CH2:20]2)[N:5]=[C:4]([NH:9][C@@H:10]2[CH2:15][CH2:14][C@H:13]([C:16]([OH:18])=[O:17])[CH2:12][CH2:11]2)[N:3]=1

Participants

3

Reactant 2

HCID 18373917Acetonitrile--water (1/1)HCID 178508454HCID 178508454, compound

Product 1

HCID 178508803HCID 178508803, compound

Procedure

To the solution of crude cis-4-(4-amino-6-chloro-1,3,5-triazin-2-ylamino)cyclohexanecarboxylic acid (˜0.46 mmol) in CH3CN/H2O (5 ml/1 ml) was added hexamethyleneimine (240 μl, ˜5 equivalents). The reaction mixture was stirred at room temperature overnight. The reaction solution was condensed and the crude product was purified by RP-HPLC (Luna 5μ C8(2), 100×21 mm, 15-65% CH3CN/H2O, 0.1% TFA, 18 min) to give the product (65 mg). MS (ES+): m/e 335.3 [M+H]+.

Workup

  1. customcondensed
  2. customthe crude product was purified by RP-HPLC (Luna 5μ C8(2), 100×21 mm, 15-65% CH3CN/H2O, 0.1% TFA, 18 min)

Sources & evidence

ORD record
ord-c65b873d9adc470bbe42415da80105be
Source dataset
uspto-grants-2011_08
Patent number
US07994317B2

Reaction notes

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