関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 4-Chloro-N-methyl-6-(4-methylpiperazin-1-yl)-1,3,5-triazin-2-amine | HCID 80767500 | — |
| 反応物 | HCID 178511567 | HCID 178511567 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | HCID 178482424 | HCID 178482424 | 12.8% |
反応手順
trans-4-Aminocyclohexylcarboxylic acid (472 mg, 3.30 mmol, 8 equivalents) and triethylamine (0.46 ml, 3.30 mmol, 8 equivalents) was added to the solution of 4-Chloro-N-methyl-6-(4-methylpiperazin-1-yl)-1,3,5-triazin-2-amine (100 mg, 0.412 mmol, 1 equivalent) in CH3CN (8 ml). The reaction mixture was heated at 80° C. for 16 hours. The solvent was evaporated and the crude product was purified with RP-HPLC (Luna 5μ, C8(2), 100×21 mm, 2-45% CH3CN/H2O, 0.1% TFA, 25 min) to give the product (18.4 mg, 10%). MS (ES+): m/e 350.13 [M+H]+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07994317B2 |
|---|
| 出典データセット | uspto-grants-2011_08 |
|---|
| ORD ID | ord-9169c6f2e0974c4aa8fde5dc2f6eb1f0 |
|---|
| 出典メモ | uspto-grants-2011_08 |
|---|
