Sodium Thiosulfate → HCID 86761391, compound

Participants

Reaction Steps

To a solution of 2-(ethylthio)-6-(3-(2-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)pyridine-3-amine (1.00 g, 3.04 mmol, 1.0 eq.) in THF (100 mL) under nitrogen at 0° C. was added MCPBA (77%, 1.60 g, 9.27 mmol, 3.05 eq.). After 3 h 15 min, 5% aqueous sodium thiosulfate and saturated aqueous NaHCO3 were added, and the solution was stirred for 10 min. CH2Cl2 was then added, and the layers were separated. The aqueous layer was extracted with CH2Cl2 (2×), and the organic layers were combined, dried over Na2SO4, filtered, and concentrated in vacuo. Trituration with EtOAc afforded 2-ethylsulfonyl)-6(3-(2-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)pyridine-3-amine as a light tan solid (0.94 g, 85% yield).

Provenance & Evidence