4-Bromobiphenyl → HCID 67337164, compound

Participants

Reaction Conditions

Reaction Steps

Under a stream of argon, 2.8 ml of a hexane solution containing 4.3 mmol of butyl lithium was slowly added to 15 ml of tetrahydrofuran cooled to −78° C. in which prepared by dissolving 0.91 g of 4-bromobiphenyl. After stirring at −78° C. for 15 minutes, 1.19 g of dichloro(tetramethylethylenediamine)zinc(II) was added thereto and stirred at −78° C. for 10 minutes and then at room temperature for 2 hours. A 1.47 g portion of 2-(4-bromophenyl)-4,6-bis(1-naphthyl)-1,3,5-triazine prepared in Reference Example 4 and 0.14 g of tetrakis(triphenylphosphine)palladium(0) were dissolved in 80 ml of tetrahydrofuran and added to this solution, followed by stirring under heating reflux for 13 hours. The reaction solution was concentrated under a reduced pressure and the thus obtained solid was washed with chloroform to obtain a white solid of the intended 2,4-bis(1-naphthyl)-6-[1,1′:4′,1″]terphenyl-4-yl-1,3,5-triazine (1.19 g, yield 71%).

Provenance & Evidence